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Advanced filters: Author: Matthew J. Eramo Clear advanced filters

  • The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endosome formation and trafficking that leads to the activation of Wnt/β-catenin signalling.

    • Samuel J. Rodgers
    • Lisa M. Ooms
    • Christina A. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19