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Showing 1–12 of 12 results
Advanced filters: Author: Matthew J. Paszek Clear advanced filters

  • A nanoscale polymer layer formed by mucins at the surface of tumour cells protects them against immune cell attack. This shield can be circumvented through immune cell engineering, using chimeric antigen receptors to stimulate natural killer and T cells or by tethering glycocalyx-editing enzymes to immune cells.

    • Sangwoo Park
    • Marshall J. Colville
    • Matthew J. Paszek
    Research
    Nature Materials
    Volume: 23, P: 429-438

  • This paper reports a fluorescence imaging method based on interference contrast in which the incidence angle of the excitation light is actively scanned. The high axial precision and temporal resolution are used for dynamic nanoscale imaging of cytoskeleton and adhesion proteins in living cells.

    • Matthew J Paszek
    • Christopher C DuFort
    • Valerie M Weaver
    Research
    Nature Methods
    Volume: 9, P: 825-827

  • Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins, and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins — by funnelling integrins into adhesions, integrin clustering and signalling is promoted, which leads to enhanced cell survival and proliferation.

    • Matthew J. Paszek
    • Christopher C. DuFort
    • Valerie M. Weaver
    Research
    Nature
    Volume: 511, P: 319-325

  • Wittmann and colleagues demonstrate that the turnover of mature focal adhesions is regulated by CLASP proteins. They show that CLASP recruitment to focal adhesions is involved in localized exocytosis and extracellular matrix degradation, suggesting that local matrix metalloprotease secretion might promote focal adhesion disassembly.

    • Samantha J. Stehbens
    • Matthew Paszek
    • Torsten Wittmann
    Research
    Nature Cell Biology
    Volume: 16, P: 558-570

  • In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.

    • Allison J. Bancroft
    • Colin W. Levy
    • Richard K. Grencis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • An orthogonal O-glycan biosynthesis system was engineered in Escherichia coli to support the production of glycoproteins displaying human mucin O-glycans, including Tn antigens, in living bacteria and in cell-free extracts.

    • Aravind Natarajan
    • Thapakorn Jaroentomeechai
    • Matthew P. DeLisa
    Research
    Nature Chemical Biology
    Volume: 16, P: 1062-1070

  • Cells exist within a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. Disrupting these cues compromises tensional homeostasis, which suggests that there is complex interplay between the extracellular microenvironment and cellular function. As alterations in the extracellular matrix can sustain perturbed tensional homeostasis, it serves as a mechanically based memory-storage device.

    • Christopher C. DuFort
    • Matthew J. Paszek
    • Valerie M. Weaver
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 308-319

  • It may look like little more than slime, but the glycocalyx coating our cells plays a key role in cell signalling. And changes to its physical structure have been linked to cancer, triggering emergent behaviours that form the focus of this Review.

    • Joe Chin-Hun Kuo
    • Jay G. Gandhi
    • Matthew J. Paszek
    Reviews
    Nature Physics
    Volume: 14, P: 658-669