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Showing 1–6 of 6 results
Advanced filters: Author: Matthew M. Guzzo Clear advanced filters

  • Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.

    • Patrick S. Tarpey
    • Sam Behjati
    • Peter J. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-6

  • Clinical staging of muscle-invasive bladder cancer remains limited by volume criteria used to identify nodal metastases. The development of accurate predictive models that identify patients at high risk of nodal disease, such as the one described here, is essential to optimize treatment planning for this group of patients.

    • Matthew J. Resnick
    • Thomas J. Guzzo
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 360-361

  • The optimum management of patients with low-stage seminoma remains a matter of debate. Here, Resnick et al. detail the case of a 51-year-old man who was diagnosed with bilateral stage I testicular seminoma. The authors discuss the management of bilateral disease, addressing the implications of surgical castration and the possibility of testis-sparing approaches to treatment.

    • Matthew J Resnick
    • Daniel Canter
    • Alan J Wein
    Reviews
    Nature Clinical Practice Urology
    Volume: 5, P: 397-401

  • Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.

    • Frank Penkava
    • Martin Del Castillo Velasco-Herrera
    • M. Hussein Al-Mossawi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Climate change is spatially asymmetrical and so will alter the behaviour of generalist consumer species, affecting food webs in two ways. Movement into novel ecosystems will affect the topology of food webs, while changes within an ecosystem will affect interaction strengths.

    • Timothy J. Bartley
    • Kevin S. McCann
    • Bailey C. McMeans
    Reviews
    Nature Ecology & Evolution
    Volume: 3, P: 345-354

  • Arctic lakes and their resident fish species are warming rapidly. Geospatial analysis of Canadian Arctic lakes predicts a 20% increase in lake trout productivity by 2050 and a 29% increase in harvestable biomass across an expanded range.

    • Steven E. Campana
    • John M. Casselman
    • Robert Perry
    Research
    Nature Climate Change
    Volume: 10, P: 428-433