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Showing 1–15 of 15 results
Advanced filters: Author: Matthew M. Hedman Clear advanced filters

  • A hitherto undetected disk of debris around Saturn is the largest ever found to be orbiting a planet. This ring may hold the key to one of the most enigmatic landscapes in the Solar System.

    • Matthew S. Tiscareno
    • Matthew M. Hedman
    News & Views
    Nature
    Volume: 461, P: 1064-1065

  • The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.

    • Benjamin B. Sun
    • Joshua Chiou
    • Christopher D. Whelan
    ResearchOpen Access
    Nature
    Volume: 622, P: 329-338

  • Three mysterious features at Titan’s northern polar region appear as lakes when observed with Cassini’s radar during winter but as land when observed in the infrared during spring, providing evidence of liquid removal on Titan at seasonal scale.

    • Shannon M. MacKenzie
    • Jason W. Barnes
    • Christophe Sotin
    Research
    Nature Astronomy
    Volume: 3, P: 506-510

    • Matthew M. Hedman
    News & Views
    Nature Astronomy
    Volume: 1, P: 580

  • An object in the distant Solar System has been shown to have a ring that is unusually far from its host — prompting speculation about how the ring material has avoided clumping together to form moons.

    • Matthew M. Hedman
    News & Views
    Nature
    Volume: 614, P: 232-233

  • A retrospective analysis using PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing finds an association between adeno-associated virus type 2 and paediatric hepatitis of unknown cause.

    • Venice Servellita
    • Alicia Sotomayor Gonzalez
    • Charles Y. Chiu
    Research
    Nature
    Volume: 617, P: 574-580

  • This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.

    • Tuomas O. Kilpeläinen
    • Jayne F. Martin Carli
    • Ruth J. F. Loos
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

    • Pradeep Natarajan
    • Akhil Pampana
    • Gina M. Peloso
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

    • Erik L. Bao
    • Satish K. Nandakumar
    • Vijay G. Sankaran
    Research
    Nature
    Volume: 586, P: 769-775

  • Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

    • Puya Gharahkhani
    • Eric Jorgenson
    • Janey L. Wiggs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Postpartum involution of the mammary gland is a recognized risk factor for breast cancer. This report identifies a mechanism that could be at least partially responsible for the increased risk, involving both the elevated expression of COX-2 and its interaction with extracellular collagen, the deposition of which occurs during postpartum involution. Both these factors promote tumor growth and invasion in mice and correlate with poor prognosis in young women with breast cancer. The data suggest that ibuprofen treatment during involution is a safe and effective approach to diminish pregnancy-associated cancer.

    • Traci R Lyons
    • Jenean O'Brien
    • Pepper Schedin
    Research
    Nature Medicine
    Volume: 17, P: 1109-1115