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Showing 1–15 of 15 results
Advanced filters: Author: Matthew M. Hufford Clear advanced filters

  • Maize originated in southern Mexico from domestication of the wild grass teosinte, and diffused throughout the Americas. Sequenced DNA from archaeological samples spanning 6,000 years, documents the diffusion route and reveals the genes that were specifically selected for climatic and cultural adaptation to the US Southwest.

    • Rute R. da Fonseca
    • Bruce D. Smith
    • M. Thomas P. Gilbert
    Research
    Nature Plants
    Volume: 1, P: 1-5

  • Genome-wide association analysis for morphological traits across 350 elite maize inbred lines in Chinese and US germplasm identifies loci and genomic regions representing the targets of selection during modern maize breeding.

    • Baobao Wang
    • Zechuan Lin
    • Haiyang Wang
    Research
    Nature Genetics
    Volume: 52, P: 565-571

  • A high-density genomic variation map from 744 genomes encompassing maize and all wild taxa of the genus Zea reveals evidence of adaptive variation and provides a genus-wide resource of genetic diversity in Zea.

    • Lu Chen
    • Jingyun Luo
    • Jianbing Yan
    Research
    Nature Genetics
    Volume: 54, P: 1736-1745

  • Sequence depth and read length determine the quality of genome assembly. Here, the authors leverage a set of PacBio reads to develop guidelines for sequencing and assembly of complex plant genomes in order to allocate finite resources using maize as an example.

    • Shujun Ou
    • Jianing Liu
    • Doreen Ware
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The pathogenesis of inflammatory bowel disease is orchestrated by specific subsets of cytokine-secreting T cells. The interleukin 9–producing subset of helper T cells contributes to the pathogenesis of inflammatory bowel disease in part by disrupting intestinal barrier function and impairing tissue-repair mechanisms.

    • Matthew M Hufford
    • Mark H Kaplan
    News & Views
    Nature Immunology
    Volume: 15, P: 599-600

  • A complete telomere-to-telomere genome assembly of the maize Mo17 inbred line uncovers structural features of the highly complex maize genome.

    • Jian Chen
    • Zijian Wang
    • Jinsheng Lai
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1221-1231

  • A study using population genomic data of domesticated and wild maize shows that purifying selection plays a major role in shaping maize diversity, and the efficacy of purifying selection increased following post-domestication population expansion.

    • Timothy M. Beissinger
    • Li Wang
    • Jeffrey Ross-Ibarra
    Research
    Nature Plants
    Volume: 2, P: 1-7

  • Jeff Ross-Ibarra and colleagues report a population genomic analysis of maize evolution. They analyze genome-wide evidence for selection during the initial domestication of wild maize and during the improvement of landraces to modern inbred breeds. Their findings suggest stronger selection during domestication compared to improvement.

    • Matthew B Hufford
    • Xun Xu
    • Jeffrey Ross-Ibarra
    Research
    Nature Genetics
    Volume: 44, P: 808-811

  • This Review summarizes our current understanding of the key factors that regulate the differentiation of T helper 9 (TH9) cells. The authors discuss how TH9 cells can contribute to protective immunity to infection but may also drive immunopathology in diseases such as allergic asthma and inflammatory bowel disease.

    • Mark H. Kaplan
    • Matthew M. Hufford
    • Matthew R. Olson
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 295-307

  • The nucleotide diversity present in maize exceeds that in humans by an order of magnitude, and it has been challenging to characterize the high levels of diversity in this important crop. Doreen Ware and colleagues have identified 55 million SNPs in 103 domesticated and pre-domestication Zea mays varieties, as well as in a representative from the sister genus Tripsacum.

    • Jer-Ming Chia
    • Chi Song
    • Doreen Ware
    Research
    Nature Genetics
    Volume: 44, P: 803-807

  • Peter Taylor and colleagues provide an overview of the neutralizing monoclonal antibody therapies that have been developed to target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and discuss the clinical utility of these antibodies.

    • Peter C. Taylor
    • Andrew C. Adams
    • Robert L. Gottlieb
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 382-393