Nature Search

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

Renally clearable gold quantum clusters that are stabilized by the milk metalloprotein alpha-lactalbumin and display multicolour fluorescence aid the detection, resection and treatment of breast cancer in mice.

Jiang Yang
Tai Wang
Moritz F. Kircher
Research13 Jul 2020
Nature Biomedical Engineering

Volume: 4, P: 686-703
β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

Phagocytosis is regulated by the mechanical properties of both the phagocyte and its cargo. Here, the authors show that macrophages employ β2 integrins to sense the rigidity of phagocytic cargo and then mount the appropriate form of engulfment.

Alexander H. Settle
Benjamin Y. Winer
Morgan Huse
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-20
HLA-independent T cell receptors for targeting tumors with low antigen density

HLA-independent T cell receptors, in which the heavy and light chains of a chimeric antigen receptor are incorporated into the endogenous T cell receptor locus, are more effective than CD28-based chimeric antigen receptors at targeting tumors with low antigen expression.

Jorge Mansilla-Soto
Justin Eyquem
Michel Sadelain
Research13 Jan 2022
Nature Medicine

Volume: 28, P: 345-352
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Acute loss of H3K4me3 does not have detectable effects on transcriptional initiation, but leads to a widespread decrease in transcriptional output, an increase in RNA polymerase II pausing and slower elongation

Hua Wang
Zheng Fan
Kristian Helin
ResearchOpen Access01 Mar 2023
Nature

Volume: 615, P: 339-348
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Copper depletion has been reported to improve survival in patients with triple negative breast cancer (TNBC) but the underlying mechanisms are not completely understood. Here, the authors show that copper chelation reduces mitochondrial oxidative phosphorylation leading to decreased TNBC metastasis.

Divya Ramchandani
Mirela Berisa
Vivek Mittal
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-16
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Anti-PD-1 secreted by CAR-T cells remains localized to the tumor and improves therapeutic outcome in mice.

Sarwish Rafiq
Oladapo O Yeku
Renier J Brentjens
Research13 Aug 2018
Nature Biotechnology

Volume: 36, P: 847-856
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Chimeric antigen receptors (CARs) promote antigen loss in tumour cells by trogocytosis, which results in T cell fratricide killing and exhaustion but can be counteracted by cooperative killing and combinatorial targeting.

Mohamad Hamieh
Anton Dobrin
Michel Sadelain
Research27 Mar 2019
Nature

Volume: 568, P: 112-116
Olfactory behavior and physiology are disrupted in prion protein knockout mice

The normal physiological function of the prion protein PrP^C remains unknown. Here, the authors report that PrP knockout mice show altered behavior in two olfactory tasks and that PrP deficiency affects oscillatory activity in the olfactory bulb. Both the behavioral and electrophysiological phenotypes could be rescued by transgenic neuronal-specific expression of PrP^C.

Claire E Le Pichon
Matthew T Valley
Stuart Firestein
Research21 Dec 2008
Nature Neuroscience

Volume: 12, P: 60-69
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities

Atsushi Tanaka
Makiko Ogawa
Michael H. A. Roehrl
ResearchOpen Access03 Oct 2024
npj Precision Oncology

Volume: 8, P: 1-13
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17

Search

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

HLA-independent T cell receptors for targeting tumors with low antigen density

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Olfactory behavior and physiology are disrupted in prion protein knockout mice

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

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