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Showing 1–4 of 4 results
Advanced filters: Author: Matthew R. Pawlak Clear advanced filters
  • Mechanical forces drive critical cellular processes, but methods to study such cellular forces are typically low-throughput. Here the authors present a method using “Rupture And Deliver” Tension Gauge Tethers, where flow cytometry or sequencing can be used to record the mechanical history of thousands of individual cells.

    • Matthew R. Pawlak
    • Adam T. Smiley
    • Wendy R. Gordon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • Mars, an attractive candidate for potential presence of extraterrestrial life, contains oxychlorine species such as perchlorate at its surface. Here, the authors show perchlorate brines support folding and catalysis of functional RNAs, while inactivating representative protein enzymes, and that perchlorate enables new ribozyme functions, including ribozyme catalyzed chlorination of organic molecules.

    • Tanner G. Hoog
    • Matthew R. Pawlak
    • Aaron E. Engelhart
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • Phenotypic screening for serine hydrolase inhibitors capable of modulating lipid storage coupled with target deconvolution identifies carboxylesterase 3 as having a role in regulating adipocyte function, with enzyme inhibition causing positive outcomes in mouse models of obesity and diabetes.

    • Eduardo Dominguez
    • Andrea Galmozzi
    • Enrique Saez
    Research
    Nature Chemical Biology
    Volume: 10, P: 113-121