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Showing 1–3 of 3 results
Advanced filters: Author: Matthew S. Koletsky Clear advanced filters

  • In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expression and methylation compared to A-D-M wild type cases- these gene expression differences suggest that A-D-M mutant PanNETs potentially originate from a cell type similar to alpha cells.

    • Chang S. Chan
    • Saurabh V. Laddha
    • Laura H. Tang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Osteosarcoma typically occurs during the adolescent growth spurt and is the most common primary cancer of bone. Here, Sharon A. Savage and colleagues discuss how advances in germline and somatic genetics, tumour biology and animal models have enhanced our understanding of osteosarcoma aetiology and could lead to new therapeutic approaches to treat the disease.

    • D. Matthew Gianferante
    • Lisa Mirabello
    • Sharon A. Savage
    Reviews
    Nature Reviews Endocrinology
    Volume: 13, P: 480-491