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The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

The success of allogeneic hematopoietic stem cell transplantation for the treatment of haematological cancers is limited by the morbidity and mortality associated with graft-versus-host disease (GVHD). Here the authors show that the microbial metabolite desaminotyrosine contributes to graft-versus-leukemia responses while protecting against GVHD and promoting mTORC1 and STING-dependent intestinal regeneration.

Sascha Göttert
Erik Thiele Orberg
Hendrik Poeck
ResearchOpen Access20 Oct 2025
Nature Communications

Volume: 16, P: 1-26
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.

Katrin Fischer
Anna Fenzl
Timo D. Müller
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-13
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes

Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.

Kerstin Renner
Tobias Schwittay
Matthias Mack
ResearchOpen Access21 May 2021
Nature Communications

Volume: 12, P: 1-11
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Poeck and colleagues identify a microbiome signature in patients receiving allogenic stem cell transplantation, which is associated with protective immune-modulatory metabolites, improved survival and less transplant-related mortality.

Erik Thiele Orberg
Elisabeth Meedt
Hendrik Poeck
Research03 Jan 2024
Nature Cancer

Volume: 5, P: 187-208
Experimental demonstration of attosecond pump–probe spectroscopy with an X-ray free-electron laser

Researchers have demonstrated the generation and control of subfemtosecond pulse pairs from a two-colour X-ray free-electron laser and conducted pump–probe experiments in core-ionized molecules.

Zhaoheng Guo
Taran Driver
Agostino Marinelli
Research11 Apr 2024
Nature Photonics

Volume: 18, P: 691-697
The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization

A genome assembly of the sterlet, Acipenser ruthenus, reveals a whole-genome duplication early in the evolution of the entire sturgeon lineage and provides details about the rediploidization of the genome.

Kang Du
Matthias Stöck
Manfred Schartl
ResearchOpen Access30 Mar 2020
Nature Ecology & Evolution

Volume: 4, P: 841-852
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Identifying causal variants and genes in genome-wide association studies remains a challenge, an issue that is ameliorated with larger sample sizes. Here the authors meta-analyze kidney function genome-wide association studies to identify new loci and fine-map loci to home in on variants and genes involved in kidney function.

Kira J. Stanzick
Yong Li
Thomas W. Winkler
ResearchOpen Access16 Jul 2021
Nature Communications

Volume: 12, P: 1-17
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

Targeting thermogenesis in brown fat and skeletal muscle to expend energy and reduce fat mass is a promising therapeutic strategy for treating obesity and related metabolic diseases. Here, Betz and Enerbäck discuss the different molecular pathways regulating thermogenesis in these organs and discuss how they can be therapeutically exploited.

Matthias J. Betz
Sven Enerbäck
Reviews23 Oct 2017
Nature Reviews Endocrinology

Volume: 14, P: 77-87
“The antibiotic paradox” in allogeneic stem cell transplantation

Daniela Weber
Elisabeth Meedt
Ernst Holler
CorrespondenceOpen Access04 Sept 2025
Bone Marrow Transplantation

Volume: 60, P: 1541-1543
Annual and sub-seasonal dynamics of a rapidly eroding permafrost coastline along the Beaufort Sea in northern Alaska

Melissa K. Ward Jones
Benjamin M. Jones
Diana Bull
ResearchOpen Access05 Jun 2025
Scientific Reports

Volume: 15, P: 1-16
Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD

Kathrin Burgmaier
Samuel Kilian
Hulya Nalcacioglu
ResearchOpen Access04 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Unpredicted ecosystem response to compound human impacts in a European river

Jan Köhler
Elisabeth Varga
Tobias Goldhammer
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-12
Fifty years of limnological data on Lake Stechlin, a temperate clearwater lake

Sabine Wollrab
Silke R. Schmidt
Rainer Koschel
ResearchOpen Access18 Jun 2025
Scientific Data

Volume: 12, P: 1-10
Design and implementation of an illumination system to mimic skyglow at ecosystem level in a large-scale lake enclosure facility

Andreas Jechow
Günther Schreck
Franz Hölker
ResearchOpen Access06 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Severe neurological outcomes after very early bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD)

Kathrin Burgmaier
Gema Ariceta
Hulya Nalcacioglu
ResearchOpen Access29 Sept 2020
Scientific Reports

Volume: 10, P: 1-12
Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Kathrin Burgmaier
Samuel Kilian
Max C. Liebau
ResearchOpen Access28 May 2019
Scientific Reports

Volume: 9, P: 1-11

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