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Showing 1–5 of 5 results
Advanced filters: Author: Matthias Rottmann Clear advanced filters

  • Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

    • Nicolas M. B. Brancucci
    • Christin Gumpp
    • Till S. Voss
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • The lipid kinase phosphatidylinositol-4-OH kinase (PI(4)K) is identified as a target of the imidazopyrazines, a new antimalarial compound class that can inhibit several Plasmodium species at each stage of the parasite life cycle; the imidazopyrazines exert their inhibitory action by interacting with the ATP-binding pocket of PI(4)K.

    • Case W. McNamara
    • Marcus C. S. Lee
    • Elizabeth A. Winzeler
    Research
    Nature
    Volume: 504, P: 248-253

  • Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.

    • Suneesh Kumar Pachathundikandi
    • Nicole Tegtmeyer
    • Steffen Backert
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

    • Michael Janssen
    • Heino Falcke
    • Shan-Shan Zhao
    ResearchOpen Access
    Nature Astronomy
    Volume: 5, P: 1017-1028