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Showing 1–2 of 2 results
Advanced filters: Author: Matthieu Fonvielle Clear advanced filters

  • Blocking peptidoglycan synthesis kills bacteria. The authors show that the E. faecium PBP5 peptidoglycan binding site is distal to the active site, which could be the focus of antibiotic strategies that hinder substrate recruitment.

    • Yamanappa Hunashal
    • Matthieu Fonvielle
    • Wolfgang Peti
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into YcbB-mediated antibiotic resistance.

    • Nathanael A. Caveney
    • Guillermo Caballero
    • Natalie C. J. Strynadka
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11