Nature Search

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling

Trumpp and colleagues develop a method to obtain long-term circulating tumor cell-derived organoids from individuals with metastatic breast cancer and identify the neuregulin 1–HER3 axis as important for organoid growth and a promising therapeutic target.

Roberto Würth
Elisa Donato
Andreas Trumpp
ResearchOpen Access03 Jan 2025
Nature Cancer

Volume: 6, P: 67-85
Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

Simon Raffel
Mattia Falcone
Andreas Trumpp
Amendments and Corrections01 Aug 2018
Nature

Volume: 560, P: E28
UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168

Ubiquitin system factors are critical regulators of DNA repair pathways. Through a functional genetic screen, the authors identify a novel role of ubiquitin-conjugating enzyme UBE2D3 in promoting DNA repair at deprotected telomeres by limiting the accumulation of RNF168 and promoting ample ATM-dependent phosphorylation of KAP1.

Zeliha Yalçin
Shiu Yeung Lam
Jacqueline J. L. Jacobs
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Phenotypic profiling of solute carriers characterizes serine transport in cancer

In this study, Papalazarou et al. screen the solute carrier family and identify candidates involved of serine transport in colorectal cancer cells. They further characterize cytosolic SLC6A14 and mitochondrial SLC25A15 as mediators of adequate serine supply to sustain cancer cell proliferation.

Vasileios Papalazarou
Alice C. Newman
Oliver D. K. Maddocks
ResearchOpen Access08 Dec 2023
Nature Metabolism

Volume: 5, P: 2148-2168
Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3

Congenital limb defects are often associated with genomic rearrangements. Here they provide insights into the molecular mechanism underlying SHFM3-associated structural variations, offering a conceptual framework for how genomic rearrangements can alter gene expression and cause disease.

Giulia Cova
Juliane Glaser
Stefan Mundlos
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-17
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner

MAD2L2 – as a member of the shieldin complex - counteracts resection during DNA repair. Here the authors demonstrate that MAD2L2 protects stalled replication forks from excessive resection, in a shieldin-independent and REV3L-dependent manner.

Inés Paniagua
Zainab Tayeh
Jacqueline J. L. Jacobs
ResearchOpen Access08 Sept 2022
Nature Communications

Volume: 13, P: 1-17
Publisher Correction: Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3

Giulia Cova
Juliane Glaser
Stefan Mundlos
Amendments and CorrectionsOpen Access18 May 2023
Nature Communications

Volume: 14, P: 1
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

The mechanistic basis for the role of the metabolic enzyme BCAA transaminase 1 (BCAT1) in acute myeloid leukaemias.

Simon Raffel
Mattia Falcone
Andreas Trumpp
Research08 Nov 2017
Nature

Volume: 551, P: 384-388
The KRAS-BCAA-BCAT2 axis in PDAC development

Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early stages of tumor development, providing insights that could stimulate novel therapeutic strategies.

Mattia Falcone
Oliver D. K. Maddocks
News & Views06 Feb 2020
Nature Cell Biology

Volume: 22, P: 139-140
Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Anna M. Paczulla
Kathrin Rothfelder
Claudia Lengerke
Amendments and Corrections01 Aug 2019
Nature

Volume: 572, P: E19
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Transcriptional profiling of Kras-driven early lesions—aimed at identifying founder events—reveals DDR1 as a therapeutic target relevant to adenocarcinoma.

Chiara Ambrogio
Gonzalo Gómez-López
Mariano Barbacid
Research08 Feb 2016
Nature Medicine

Volume: 22, P: 270-277
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation

Mattia Falcone
Alejandro Huerta Uribe
Oliver D. K. Maddocks
ResearchOpen Access17 Sept 2022
British Journal of Cancer

Volume: 127, P: 1773-1786
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Leukaemic stem cells in acute myeloid leukaemia are defined by a lack of expression of NKG2D ligands, which mediates their ability to evade surveillance by NK cells.

Anna M. Paczulla
Kathrin Rothfelder
Claudia Lengerke
Research17 Jul 2019
Nature

Volume: 572, P: 254-259
SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production

Mattia Falcone
Oliver D. K. Maddocks
Research HighlightsOpen Access24 Nov 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-2

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Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168

Mapping the human genetic architecture of COVID-19

Phenotypic profiling of solute carriers characterizes serine transport in cancer

Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3

MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner

Publisher Correction: Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3

A second update on mapping the human genetic architecture of COVID-19

BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

The KRAS-BCAA-BCAT2 axis in PDAC development

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Whole-genome sequencing reveals host factors underlying critical COVID-19

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Sensitisation of cancer cells to radiotherapy by serine and glycine starvation

A first update on mapping the human genetic architecture of COVID-19

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production

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