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Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos
Eric R. Fearon
Bert Vogelstein
Research28 May 1987
Nature

Volume: 327, P: 293-297
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

Johannes L. Bos
Deniz Toksoz
Ada C. M. Steenvoorden
Research01 Jun 1985
Nature

Volume: 315, P: 726-730
The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

Transcription-Coupled Nucleotide Excision Repair (TC-NER) removes transcription-blocking DNA lesions. This study reveals that DDA1 is a crucial player in TC-NER, protecting transcription programs against genotoxic insults.

Diana A. Llerena Schiffmacher
Shun-Hsiao Lee
Alex Pines
ResearchOpen Access29 Jul 2024
Nature Communications

Volume: 15, P: 1-17
SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

The authors show that the SUMO protease SENP6 plays an essential role in maintaining genome integrity by disassembling SUMO2/3 polymers from DNA damage response proteins, thereby preventing their trapping at sites of DNA damage and in nuclear condensates.

Laura A. Claessens
Matty Verlaan-de Vries
Alfred C. O. Vertegaal
ResearchOpen Access22 Sept 2023
Nature Communications

Volume: 14, P: 1-19
The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

While the biological roles of ubiquitin chains are well studied, little is known about the functions of SUMO polymers. Here, the authors identify poly-SUMOylation substrates and provide evidence that SUMO polymers regulate the accumulation of CCAN subunits at chromatin and centromeres.

Frauke Liebelt
Nicolette S. Jansen
Alfred C. O. Vertegaal
ResearchOpen Access04 Sept 2019
Nature Communications

Volume: 10, P: 1-18
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4 substrates.

Ramesh Kumar
Román González-Prieto
Alfred C. O. Vertegaal
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-16
Uncovering global SUMOylation signaling networks in a site-specific manner

High-resolution MS identifies >4,300 SUMOylation sites in >1,600 proteins in human cells under standard growth conditions and after proteasome inhibition or heat shock. The data reveal cross-talk between SUMO and other post-translational modifications.

Ivo A Hendriks
Rochelle C J D'Souza
Alfred C O Vertegaal
Research14 Sept 2014
Nature Structural & Molecular Biology

Volume: 21, P: 927-936

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Prevalence of ras gene mutations in human colorectal cancers

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Uncovering global SUMOylation signaling networks in a site-specific manner

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Prevalence of ras gene mutations in human colorectal cancers

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Uncovering global SUMOylation signaling networks in a site-specific manner

Search

Quick links

The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics