Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Maud H. W. Starmans Clear advanced filters

  • Reduced expression of DICER—responsible for the processing of microRNA precursors—was previously linked to poor clinical outcomes in cancer patients. Here, the authors uncover an epigenetic mechanism by which hypoxia suppresses DICER expression and deregulates the miR-200-Zeb1 circuit in breast cancer to promote the tumour phenotype.

    • Twan van den Beucken
    • Elizabeth Koch
    • Bradly G. Wouters
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • Accurate and actionable biomarkers that integrate diverse molecular, functional and clinical information hold great promise in precision medicine. Here, the authors develop SIMMS, a method for pathway-based cross-disease biomarker discovery.

    • Syed Haider
    • Cindy Q. Yao
    • Paul C. Boutros
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.

    • Paul C Boutros
    • Michael Fraser
    • Robert G Bristow
    Research
    Nature Genetics
    Volume: 47, P: 736-745

  • The emergence of individualized medicine has spurred the need for the development of clinical decision-support systems (CDSSs) based on prediction models of treatment outcome. In radiation oncology, CDSSs combine clinical, imaging and molecular factors to achieve the highest accuracy to predict tumour response. Here, the authors provide an overview of these factors—including survival, recurrence patterns and toxicity—and discuss the methodology behind the multistage development of CDSSs.

    • Philippe Lambin
    • Ruud G. P. M. van Stiphout
    • Andre Dekker
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 10, P: 27-40