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Showing 1–2 of 2 results
Advanced filters: Author: Maurie Balch Clear advanced filters

  • The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease. Here the authors report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

    • Sheng Chen
    • Anuradhika Puri
    • Meredith E. Jackrel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform.

    • Anuj Khandelwal
    • Caitlin N. Kent
    • Brian S. J. Blagg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7