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Showing 1–3 of 3 results
Advanced filters: Author: Mauro D. Locati Clear advanced filters

  • Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative stress and reduced oxygen tension in culture lowers mutation rates.

    • Ewart Kuijk
    • Myrthe Jager
    • Edwin Cuppen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of mutations, nor an alteration of mutation types in individual liver stem cells.

    • Luan Nguyen
    • Myrthe Jager
    • Ewart Kuijk
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9