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Showing 1–9 of 9 results
Advanced filters: Author: Maxence S. Vincent Clear advanced filters

  • No structural data for the bacterial type IX secretion system (T9SS) are available so far. Here, the authors present the crystal structures of the periplasmic domains from two major T9SS components PorM and GldM, which span most of the periplasmic space, and propose a putative model of the T9SS core membrane complex.

    • Philippe Leone
    • Jennifer Roche
    • Alain Roussel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Swiss-PO is a new web tool to map gene mutations on the 3D structure of corresponding proteins and to intuitively assess the structural implications of protein variants for precision oncology. Swiss-PO is constructed around a manually curated database of 3D structures, variant annotations, and sequence alignments, for a list of 50 genes taken from the Ion AmpliSeqTM Custom Cancer Hotspot Panel. The website was designed to guide users in the choice of the most appropriate structure to analyze regarding the mutated residue, the role of the protein domain it belongs to, or the drug that could be selected to treat the patient. The importance of the mutated residue for the structure and activity of the protein can be assessed based on the molecular interactions exchanged with neighbor residues in 3D within the same protein or between different biomacromolecules, its conservation in orthologs, or the known effect of reported mutations in its 3D or sequence-based vicinity. Swiss-PO is available free of charge or login at https://www.swiss-po.ch.

    • Fanny S. Krebs
    • Vincent Zoete
    • Olivier Michielin
    ResearchOpen Access
    npj Precision Oncology
    Volume: 5, P: 1-9

  • The type VI secretion system (T6SS) of Gram-negative bacteria is typically anchored to the cell envelope through a membrane complex (MC), but Bacteroidota appear to lack genes encoding canonical MC components. Here, Bongiovanni et al. identify the Bacteroidota MC and study its biogenesis and connections with the conserved T6SS components.

    • Thibault R. Bongiovanni
    • Casey J. Latario
    • Eric Durand
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Spin-torque nano-oscillators have sparked interest for their potential in neuromorphic computing, however concrete demonstration are limited. Here, Romera et al show how spin-torque nano-oscillators can mutually synchronise and recognize temporal patterns, much like neurons, illustrating their potential for neuromorphic computing.

    • Miguel Romera
    • Philippe Talatchian
    • Julie Grollier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • A network of four spin-torque nano-oscillators can be trained in real time to recognize spoken vowels, in a simple and scalable approach that could be exploited for large-scale neural networks.

    • Miguel Romera
    • Philippe Talatchian
    • Julie Grollier
    Research
    Nature
    Volume: 563, P: 230-234

  • Galhaut et al. evaluate the immunogenicity and efficacy of an inactivated whole virus COVID-19 vaccine in animal models. VLA2001 adjuvanted with alum and CpG 1018 generates polyfunctional Th1 cell responses and specific neutralizing antibodies to several SARS-CoV-2 variants of concern and protects macaques from viral replication and inflammation.

    • Mathilde Galhaut
    • Urban Lundberg
    • Roger Le Grand
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-11