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Showing 1–6 of 6 results
Advanced filters: Author: Maxim S. Svetlov Clear advanced filters

  • Macrolide antibiotics halt protein synthesis in a sequence-dependent manner. Here, authors reveal a comprehensive molecular mechanism by which macrolides induce ribosome stalling selectively at Arg/Lys-X-Arg/Lys motifs in growing polypeptide chains.

    • Egor A. Syroegin
    • Elena V. Aleksandrova
    • Yury S. Polikanov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The authors discovered that hygromycin A not only enhances the cell-killing properties of macrolides but also renders them active against resistant bacteria. The provided structures of antibiotic pairs in complex with WT and macrolide-resistant ribosomes rationalize binding cooperativity of these drugs.

    • Chih-Wei Chen
    • Nadja Leimer
    • Maxim S. Svetlov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basis for the context-specific activity of macrolides on the eukaryotic ribosome.

    • Maxim S. Svetlov
    • Timm O. Koller
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The authors determined a set of structures of the methylase Cfr-methylated 70S ribosome with iboxamycin and tylosin, two antibiotics that evade Cfr-mediated drug resistance, and revealed two distinct mechanisms by which small molecules can maintain their ability to engage the Cfr-methylated ribosome.

    • Elena V. Aleksandrova
    • Kelvin J. Y. Wu
    • Yury S. Polikanov
    Research
    Nature Chemical Biology
    Volume: 20, P: 867-876

  • Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.

    • Bertrand Beckert
    • Elodie C. Leroy
    • Daniel N. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15