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Showing 1–2 of 2 results
Advanced filters: Author: Maxime Lecot Clear advanced filters

  • Structure-specific endonucleases play an important role in several DNA repair pathways. Here the authors present structures of the endonuclease XPF-ERCC1 in complex with SLX4, SLX4IP, and DNA. Combined with functional analysis, these results provide insight into the mechanisms of XPF-ERCC1 recruitment and activation during DNA repair.

    • Junjie Feng
    • Peter R. Martin
    • Basil J. Greber
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Microhomology-mediated end joining (MMEJ) and mitotic DNA synthesis (MiDAS) are critical DNA repair pathways in mitosis. Here the authors show that CIP2A–TOPBP1 coordinate mitotic DNA repair through the regulation of factors required for MiDAS and MMEJ.

    • Peter R. Martin
    • Jadwiga Nieminuszczy
    • Wojciech Niedzwiedz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25