Nature Search

Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice

May Zaw Thin
Christopher Moore
Axel Behrens
Amendments and Corrections24 Apr 2023
Nature Protocols

Volume: 18, P: 2399
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

Huafu Li
Linxiang Lan
Axel Behrens
ResearchOpen Access24 Sept 2025
Nature

Volume: 648, P: 203-209
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

The biological roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma (PDAC) are not fully explored. Here the authors perform activity based proteomics with a loss of function genetic screen and identify that USP25 promotes PDAC growth and survival through HIF-1 protein stability and transcriptional activity.

Jessica K. Nelson
May Zaw Thin
Axel Behrens
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-18
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth

Wang et al. demonstrate that CD9 marks tumour-initiating cells in pancreatic ductal adenocarcinoma (PDAC), and enhances glutamine uptake to promote tumour development in vivo that recapitulates the cellular heterogeneity of primary PDAC.

Victoria M.-Y. Wang
Rute M. M. Ferreira
Axel Behrens
Research04 Nov 2019
Nature Cell Biology

Volume: 21, P: 1425-1435
GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

The BMP inhibitor GREM1 is a key regulator of cellular heterogeneity in pancreatic cancer in human and mouse.

Linxiang Lan
Theodore Evan
Axel Behrens
Research29 Jun 2022
Nature

Volume: 607, P: 163-168
Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH

This protocol describes how to perform antigen retrieval and tissue clearing for volumetric imaging of whole organs, organoids and small organisms by using fast light-microscopic analysis of antibody-stained whole organs.

Hendrik A. Messal
Jorge Almagro
Axel Behrens
Protocols27 Nov 2020
Nature Protocols

Volume: 16, P: 239-262
Tissue clearing to examine tumour complexity in three dimensions

This Review introduces the latest advances in tissue clearing and three-dimensional imaging as applied to epithelial tissues, and explains how such techniques can improve both our understanding of tumour biology and cancer diagnostics.

Jorge Almagro
Hendrik A. Messal
Axel Behrens
Reviews30 Jul 2021
Nature Reviews Cancer

Volume: 21, P: 718-730
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice

A micro-computed X-ray tomography-based approach for quantifying the number and volume of lung cancer nodules over time, enabling the tracking of individual nodule formation, tumor growth and response to therapy.

May Zaw Thin
Christopher Moore
Axel Behrens
Protocols09 Dec 2022
Nature Protocols

Volume: 18, P: 990-1015
Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse

Sean G. Ryan
Matthew N. Butler
Mark F. Lythgoe
ResearchOpen Access16 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice

May Zaw Thin
Olumide Ogunlade
Tammy L. Kalber
ResearchOpen Access05 May 2020
Scientific Reports

Volume: 10, P: 1-12

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Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH

Tissue clearing to examine tumour complexity in three dimensions

Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice

Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse

Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice

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