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Showing 1–3 of 3 results

Advanced filters: Author: Mayumi Arata Clear advanced filters

Girolline is a sequence context-selective modulator of eIF5A activity

The marine natural product girolline is an inhibitor of protein synthesis. Here, the authors show that girolline is a sequence-selective modulator of eIF5A that can cause ribosome stalling and activate ribosome-associated quality control.

Tilman Schneider-Poetsch
Yongjun Dang
Minoru Yoshida
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-13
Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Takashi Yokota
Shintaro Kinugawa
Hiroyuki Tsutsui
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.

Shohei Takase
Takashi Hiroyama
Akihiro Ito
ResearchOpen Access12 Jan 2023
Nature Communications

Volume: 14, P: 1-18