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Showing 1–5 of 5 results
Advanced filters: Author: Mayuri Vijay Thete Clear advanced filters

  • A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.

    • Ji-il Kim
    • Kent Imaizumi
    • Sergiu P. Pașca
    ResearchOpen Access
    Nature
    Volume: 642, P: 143-153

  • Antisense oligonucleotides effectively decrease the inclusion of exon  8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons.

    • Xiaoyu Chen
    • Fikri Birey
    • Sergiu P. Pașca
    ResearchOpen Access
    Nature
    Volume: 628, P: 818-825

  • Assembloids are integrated with CRISPR screening to investigate the involvement of 425 neurodevelopmental disorder genes in human interneuron development, showing endoplasmic reticulum displacement before nuclear translocation and interference from LNPK deletion, resulting in abnormal migration.

    • Xiangling Meng
    • David Yao
    • Sergiu P. Pașca
    ResearchOpen Access
    Nature
    Volume: 622, P: 359-366