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Showing 1–9 of 9 results
Advanced filters: Author: Mazahir T. Hasan Clear advanced filters

  • Motor cortex NMDA receptors have a key role in the acquisition of associative memories. Hasan et al. generate mice lacking NMDA receptor activity in the motor cortex and find that this impairs LTP, strengthening of synapses between somatosensory and motor cortices, and associative learning.

    • Mazahir T. Hasan
    • Samuel Hernández-González
    • José M. Delgado-García
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers calcium signaling in the astrocyte and enhances SNARE-dependent astrocytic glutamate release, which is then responsible for the activation of postsynaptic NMDA receptors and synaptic depression.

    • Marta Navarrete
    • María I. Cuartero
    • José A. Esteban
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Measurement of in vivo neuronal activity with single neuron and single action potential resolution is important for studying neuronal function. Delivery of a FRET-based fluorescent Ca2+ indicator protein using adeno-associated virus results in high expression levels allowing in vivo detection of single action potentials at low firing rates. Griesbeck et al., also in this issue, describe the use of a similar sensor for recording neuronal activity in vivo.

    • Damian J Wallace
    • Stephan Meyer zum Alten Borgloh
    • Mazahir T Hasan
    Research
    Nature Methods
    Volume: 5, P: 797-804

  • The authors explore how sensory maps are reshaped by experience in vivo, using chronic two-photon calcium imaging to follow whisker-evoked activity of individual layer 2/3 neurons in adult mouse barrel cortex over weeks. By first measuring activity with whiskers intact and then with continued trimming of all but one whisker, they describe how the redistribution of population activity underlies large-scale cortical remapping.

    • David J Margolis
    • Henry Lütcke
    • Fritjof Helmchen
    Research
    Nature Neuroscience
    Volume: 15, P: 1539-1546

  • Activation of caged doxycycline or cyanodoxycycline by biologically innocuous doses of UV light allows for precise temporal and spatial control of transgene expression in hippocampal slices, mouse embryos and Xenopus laevis tadpoles.

    • Sidney B Cambridge
    • Daniel Geissler
    • Tobias Bonhoeffer
    Research
    Nature Methods
    Volume: 6, P: 527-531