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Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Markovic et al. demonstrate in rodents that anhedonia-like states in inflammatory pain are mediated through increased inhibitory control and subsequent diminished activity of mesolimbic dopamine neurons.

Tamara Markovic
Christian E. Pedersen
Jose A. Morón
Research18 Oct 2021
Nature Neuroscience

Volume: 24, P: 1601-1613
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption

Inhibition of nucleus accumbens neurons is crucial for reward consumption. Vachez, Tooley et al. characterize arkypallidal neurons in the ventral pallidum that inhibit accumbal neurons to sustain reward consumption in a value-dependent manner.

Yvan M. Vachez
Jessica R. Tooley
Meaghan C. Creed
Research25 Jan 2021
Nature Neuroscience

Volume: 24, P: 379-390
Updating the striatal–pallidal wiring diagram

Fang and Creed review and synthesize recent studies of the striatum and pallidal complex. Based on connectivity and organization of striatal–pallidal pathways in rodents, they propose how these structures coordinate learning and flexible behavior.

Lisa Z. Fang
Meaghan C. Creed
Reviews06 Dec 2023
Nature Neuroscience

Volume: 27, P: 15-27
Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain

iTango confers access to neuromodulation-sensitive subsets of neurons in a functionally defined and temporally controlled manner. The tool allows for manipulating the subset of neurons that are activated by dopamine during a behavior of interest.

Dongmin Lee
Meaghan Creed
Hyung-Bae Kwon
Research03 Apr 2017
Nature Methods

Volume: 14, P: 495-503
Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.

Sebastiano Bariselli
Nanami L. Miyazaki
Alexxai V. Kravitz
ResearchOpen Access10 Aug 2020
Nature Communications

Volume: 11, P: 1-14
Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Dopamine-independent induction of long-term potentiation at hippocampal synapses onto the nucleus accumbens modulates reward-related behaviour.

Tara A. LeGates
Mark D. Kvarta
Scott M. Thompson
Research26 Nov 2018
Nature

Volume: 564, P: 258-262
Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

Lotfi C. Hadjas
Michael M. Schartner
Linda D. Simmler
Research25 Jun 2020
Neuropsychopharmacology

Volume: 45, P: 2020-2029

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Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption

Updating the striatal–pallidal wiring diagram

Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain

Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

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Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption

Updating the striatal–pallidal wiring diagram

Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain

Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

Search

Quick links