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Showing 1–4 of 4 results
Advanced filters: Author: Medhat Shehata Clear advanced filters

  • Epigenome profiling in combination with imaging-based chemosensitivity and integrative bioinformatic analysis establishes a method for detecting therapy-induced vulnerabilities, as shown here for ibrutinib-treated chronic lymphocytic leukemia.

    • Christian Schmidl
    • Gregory I. Vladimer
    • Christoph Bock
    Research
    Nature Chemical Biology
    Volume: 15, P: 232-240

  • Anaplastic large cell lymphomas (ALCL) often express the oncoprotein NPM-ALK. This study shows that the activator protein 1 family members JUN and JUNB promote lymphoma development through platelet-derived growth factor receptor-β (PDGFRB). Inhibition of PDGFRB prolonged survival of NPM-ALK transgenic mice and increased the efficacy of an ALK-specific inhibitor against transplanted NPM-ALK tumors. Inhibition of PDGFR in a patient with ALCL also resulted in rapid, complete and sustained remission.

    • Daniela Laimer
    • Helmut Dolznig
    • Lukas Kenner
    Research
    Nature Medicine
    Volume: 18, P: 1699-1704