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Advanced filters: Author: Meerit Said Clear advanced filters

  • A series of cryo-EM structures of human IMPDH1 variants reveal polymorphic filaments. Blindness-associated mutations in IMPDH1 are characterized and half disrupt feedback inhibition. Together, these findings are a foundation for understanding IMPDH1 in retinal function and disease.

    • Anika L. Burrell
    • Chuankai Nie
    • Justin M. Kollman
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 47-58