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Nature Communications (2)

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Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells

Li et al. report that co-delivering a dominant negative fragment of p53 (p53DD) greatly enhances precise editing efficiencies for prime editing and cytosine base editing in human pluripotent stem cells, without compromising the genome-wide safety.

Mu Li
Aaron Zhong
Ting Zhou
ResearchOpen Access27 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Robust and inducible genome editing via an all-in-one prime editor in human pluripotent stem cells

Efficient and multiplex precise editing in human pluripotent stem cells (hPSCs) remains a significant challenge. Here, the authors established a robust and inducible prime editing platform, termed ‘iPE-Plus’, for efficient and controllable multiplex editing in hPSCs.

Youjun Wu
Aaron Zhong
Ting Zhou
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-13

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Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells

Robust and inducible genome editing via an all-in-one prime editor in human pluripotent stem cells

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