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Showing 1–4 of 4 results

Advanced filters: Author: Megan A. Luckey Clear advanced filters

Integrin CD103 reveals a distinct developmental pathway of autoreactive thymocytes in TCR transgenic mice

Clonal deletion is an important mechanism for the elimination of autoreactive T cells, however, negative selection of thymocytes is imperfect. Here authors show that MHC-II-restricted thymocytes avoid negative selection via downregulation of the integrin CD103, altering intra-thymic trafficking and distribution in a way that favours their survival.

Nurcin Liman
Can Li
Jung-Hyun Park
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-16
The transcription factor ThPOK suppresses Runx3 and imposes CD4⁺ lineage fate by inducing the SOCS suppressors of cytokine signaling

Lineage fate in the thymus is imposed by the antagonizing effects of the transcription factors ThPOK and Runx3. Park and colleagues show that ThPOK-induced SOCS factors are required for differentiation into the CD4⁺ T cell lineage.

Megan A Luckey
Motoko Y Kimura
Jung-Hyun Park
Research01 Jun 2014
Nature Immunology

Volume: 15, P: 638-645
Chemokine receptor CCR9 suppresses the differentiation of CD4⁺CD8αα⁺ intraepithelial T cells in the gut

Can Li
Hye Kyung Kim
Jung-Hyun Park
Research01 Jul 2022
Mucosal Immunology

Volume: 15, P: 882-895
Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus

Joo-Young Park
Yuna Jo
Changwan Hong
ResearchOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1-12

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