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Showing 1–3 of 3 results
Advanced filters: Author: Megan Chastney Clear advanced filters

  • The multidomain scaffold protein SH3 and multiple ankyrin repeat domain 3 (SHANK3) can bind GTP-bound Ras and Rap small GTPases. Here the authors show that, by binding active KRAS, SHANK3 maintains oncogenic KRAS/MAPK/ERK signaling at an optimal level while its depletion in KRAS-mutant cancer cell lines results in ERK signalling overdose and impaired cell proliferation.

    • Johanna Lilja
    • Jasmin Kaivola
    • Johanna Ivaska
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Focal adhesions are dynamic structures that link the cell to the extracellular matrix. Here, the authors report that focal adhesions contain tropomyosin-decorated actin filaments, and show evidence that suggests specific functions in adhesion dynamics and cell migration.

    • Reena Kumari
    • Katharina Ven
    • Pekka Lappalainen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Integrin receptors connect cells to the extracellular matrix, mediating cell interactions, adhesion and signalling. This Review discusses integrin function in cell migration, including integrin activation, integrin-based adhesion types and their roles in cancer cell dissemination.

    • Megan R. Chastney
    • Jasmin Kaivola
    • Johanna Ivaska
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 147-167