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Showing 1–3 of 3 results

Advanced filters: Author: Megan E. Dowdle Clear advanced filters

Cytoplasmic mRNA decay and quality control machineries in eukaryotes

In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and comment on implications for the design of therapeutic mRNAs.

Megan E. Dowdle
Jens Lykke-Andersen
Reviews27 Jan 2025
Nature Reviews Genetics

Volume: 26, P: 463-478
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.

Markus Maerker
Maike Getwan
Axel Schweickert
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16

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