Nature Search

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

Resistance to antibiotics hampers the treatment of infectious diseases such as tuberculosis (TB). Here, Farhat et al. perform genome-wide association testing for minimum inhibitory concentration (MIC) of 12 anti-TB drugs in whole-genome sequenced clinical M. tuberculosis isolates and identify 13 genomic loci.

Maha R. Farhat
Luca Freschi
Megan Murray
ResearchOpen Access13 May 2019
Nature Communications

Volume: 10, P: 1-11
A shared alarmone–GTP switch controls persister formation in bacteria

Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.

Danny K. Fung
Jessica T. Barra
Jue D. Wang
ResearchOpen Access15 May 2025
Nature Microbiology

Volume: 10, P: 1617-1629
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

Mannino et al. provide a quantitative and ultrastructural timeline of nucleophagy in yeast with lattice light sheet microscopy and correlative light and electron tomography. They identify a role for dynamin-like protein 1 in outer nuclear membrane fission.

Philip J. Mannino
Andrew Perun
C. Patrick Lusk
Research07 Feb 2025
Nature Cell Biology

Volume: 27, P: 464-476
Pseudomonas response regulators produced in an E. coli heterologous expression host exhibit host-derived post-translational phosphorylation

Megan E. Garber
Rodrigo Fregoso
Aindrila Mukhopadhyay
ResearchOpen Access20 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Buter et al. elucidated the biological function of the terpene nucleoside 1-TbAd, which is made abundantly by virulent but not avirulent Mycobacterium tuberculosis strains, and demonstrate that 1-TbAd regulates the pH and function of host macrophage endolysosomes.

Jeffrey Buter
Tan-Yun Cheng
D. Branch Moody
Research19 Aug 2019
Nature Chemical Biology

Volume: 15, P: 889-899
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

Minichromosome maintenance protein 10 (MCM10) is critical for eukaryotic DNA replication. Here, by modelling MCM10 variants in human cell lines, the authors reveal a mechanism of MCM10-associated disease, finding that loss of MCM10 function constrains telomerase activity.

Ryan M. Baxley
Wendy Leung
Anja-Katrin Bielinsky
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-19
Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice

Myelination is often compromised in ATR-X intellectual disability syndrome patients. Here, the authors show that the causative gene, ATRX, can regulate myelination in mice by modulating systemic thyroxine levels and by supporting oligodendrocyte progenitor differentiation.

Megan E. Rowland
Yan Jiang
Nathalie G. Bérubé
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-17
A functional selection reveals previously undetected anti-phage defence systems in the E. coli pangenome

Here the authors use 71 E. coli strains to generate a fosmid library that is experimentally tested for anti-phage activity and find dozens of new candidate defence systems, many of which are carried on prophage or mobile genetic elements.

Christopher N. Vassallo
Christopher R. Doering
Michael T. Laub
ResearchOpen Access19 Sept 2022
Nature Microbiology

Volume: 7, P: 1568-1579
SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses

Dominik Dornfeld
Alexandra H. Dudek
Megan L. Shaw
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
T cell-regulating therapies for autoimmune diseases take FDA rejection in stride

Despite a regulatory setback for Provention Bio’s diabetes prevention candidate teplizumab, hopes remain high for T cell-regulating therapies in autoimmune indications including multiple sclerosis, systemic lupus erythematosus and coeliac disease.

Megan Cully
News06 Aug 2021
Nature Reviews Drug Discovery

Volume: 20, P: 655-657
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA

The DarTG toxin-antitoxin system protects bacteria against phage infection via ADP-ribosylation of the viral DNA, and this can be evaded by phages via mutation of their DNA polymerase or the gp61.2 anti-DarT factor.

Michele LeRoux
Sriram Srikant
Michael T. Laub
Research20 Jun 2022
Nature Microbiology

Volume: 7, P: 1028-1040
A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

The Pseudomonas aeruginosa effector TseT is loaded into the type VI secretion system (T6SS) by the chaperone TecT. Interactions between the T6SS needle-tip protein PAAR and TecT disrupt binding between TecT and its co-chaperone, co-TecT, and promote binding of TseT to PAAR.

Brianne J. Burkinshaw
Xiaoye Liang
Tao G. Dong
Research09 Apr 2018
Nature Microbiology

Volume: 3, P: 632-640
Single-photon emission from single-electron transport in a SAW-driven lateral light-emitting diode

Electron-spin to photon-polarisation conversion is a promising technology for achieving free-space or fibre coupled quantum transfer. Here, the authors demonstrate acoustically-driven single photons from single electrons, without the need for self-assembled quantum dots, using a SAW-driven lateral n-i-p junction.

Tzu-Kan Hsiao
Antonio Rubino
Christopher J. B. Ford
ResearchOpen Access14 Feb 2020
Nature Communications

Volume: 11, P: 1-7
FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

Classically, peptidoglycan (PG) synthesis was thought to be mediated solely by class A penicillin-binding proteins (PBPs) and related enzymes, a view changed by the identification of RodA as a PG polymerase. Now FtsW is also shown to polymerize PG, in a process that requires complex formation with a partner class B PBP.

Atsushi Taguchi
Michael A. Welsh
Suzanne Walker
Research28 Jan 2019
Nature Microbiology

Volume: 4, P: 587-594
High efficiency rare earth element bioleaching with systems biology guided engineering of Gluconobacter oxydans

Using insights from whole-genome screening, the mineral-dissolving microbe Gluconobacter oxydans was engineered by deleting the pstS gene and overexpressing mgdh, creating a strain that improves rare earth element extraction by up to 73%.

Alexa M. Schmitz
Brooke Pian
Buz Barstow
ResearchOpen Access27 May 2025
Communications Biology

Volume: 8, P: 1-8
Accelerating amorphous polymer electrolyte screening by learning to reduce errors in molecular dynamics simulated properties

Screening polymer electrolytes for batteries is extremely expensive due to the complex structures and slow dynamics. Here the authors develop a machine learning scheme to accelerate the screening and explore a space much larger than past studies.

Tian Xie
Arthur France-Lanord
Jeffrey C. Grossman
ResearchOpen Access14 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

Evolutionary coupling-enabled molecular replacement determination of the structure of Thermus thermophilus RodA reveals a highly conserved cavity in its transmembrane domain, and mutagenesis experiments in Bacillus subtilis and Escherichia coli show that perturbation of this cavity abolishes RodA function.

Megan Sjodt
Kelly Brock
Andrew C. Kruse
Research28 Mar 2018
Nature

Volume: 556, P: 118-121
How Escherichia coli lands and forms cell clusters on a surface: a new role of surface topography

Huan Gu
Aaron Chen
Dacheng Ren
ResearchOpen Access14 Jul 2016
Scientific Reports

Volume: 6, P: 1-14
Multi-terminal memtransistors from polycrystalline monolayer molybdenum disulfide

Polycrystalline monolayer molybdenum disulfide is used to fabricate a multi-terminal device combining a memristor and a transistor, which can mimic biological neurons with multiple synapses for neuromorphic computing applications.

Vinod K. Sangwan
Hong-Sub Lee
Mark C. Hersam
Research22 Feb 2018
Nature

Volume: 554, P: 500-504
Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Alexiane Decout
Sandro Silva-Gomes
Jérôme Nigou
ResearchOpen Access15 Nov 2018
Scientific Reports

Volume: 8, P: 1-11
Plant-associated fungi support bacterial resilience following water limitation

Rachel Hestrin
Megan Kan
Jennifer Pett-Ridge
ResearchOpen Access09 Sept 2022
The ISME Journal

Volume: 16, P: 2752-2762
HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8⁺ T cells

Melanie J. Harriff
Lisa M. Wolfe
David M. Lewinsohn
ResearchOpen Access04 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth

Blum et al. combine computational and experimental methods to study the long-term development of tissue engineered vascular grafts in a lamb model. The authors demonstrate that the grafts undergo growth and remodeling, evolving to mimic the characteristics and function of a native blood vessel.

Kevin M. Blum
Jacob C. Zbinden
Christopher K. Breuer
ResearchOpen Access10 Jan 2022
Communications Medicine

Volume: 2, P: 1-21

Search

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

A shared alarmone–GTP switch controls persister formation in bacteria

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

Pseudomonas response regulators produced in an E. coli heterologous expression host exhibit host-derived post-translational phosphorylation

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice

A functional selection reveals previously undetected anti-phage defence systems in the E. coli pangenome

SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses

T cell-regulating therapies for autoimmune diseases take FDA rejection in stride

The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

Single-photon emission from single-electron transport in a SAW-driven lateral light-emitting diode

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

High efficiency rare earth element bioleaching with systems biology guided engineering of Gluconobacter oxydans

Accelerating amorphous polymer electrolyte screening by learning to reduce errors in molecular dynamics simulated properties

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

How Escherichia coli lands and forms cell clusters on a surface: a new role of surface topography

Multi-terminal memtransistors from polycrystalline monolayer molybdenum disulfide

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Plant-associated fungi support bacterial resilience following water limitation

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8⁺ T cells

Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth

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