Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Megan L. Schaller Clear advanced filters

  • Here the authors visualize SARS-CoV-2 infected cells by in situ cryo-electron tomography, delineating the structural organization and conformational changes that occur during virus replication and budding; and provide insight into vRNP architecture and RNA networks in double membrane vesicles.

    • Steffen Klein
    • Mirko Cortese
    • Petr Chlanda
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Sézary syndrome is a T cell malignancy that has been poorly characterized at the genome level. In this study, Kielet al. perform whole-genome analyses and identify mutations in the JAK–STAT pathway and show that primary cells are sensitive to JAK inhibitors.

    • Mark J. Kiel
    • Anagh A. Sahasrabuddhe
    • Kojo S. J. Elenitoba-Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Viral infection from the basolateral side of intestinal epithelial cells (IECs) is shown to elicit a stronger intrinsic immune response than apical infection, an effect driven by the polarized sorting of Toll-like receptor 3. Experiments in mice and human cells suggest that the cellular polarity program is integral to the ability of IECs to tolerate gut commensals while remaining responsive to invasive pathogens.

    • Megan L. Stanifer
    • Markus Mukenhirn
    • Steeve Boulant
    Research
    Nature Microbiology
    Volume: 5, P: 181-191

  • Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress resistance and slow aging in C. elegans.

    • Hyo Sub Choi
    • Ajay Bhat
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.

    • Hillary A. Miller
    • Shijiao Huang
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • TH1760 is a first-in-class, potent, selective and cell-active inhibitor against human NUDT15, which sensitizes cells to 6-thioguanine treatment. TH1760 represents a valuable tool for deciphering the enigmatic functions of NUDT15.

    • Si Min Zhang
    • Matthieu Desroses
    • Thomas Helleday
    Research
    Nature Chemical Biology
    Volume: 16, P: 1120-1128

  • Beydoun, Choi et al. develop a metabolically inactive food source for C. elegans worms that minimizes the confounding effects of bacterial metabolism on worm metabolism and aging. They find that worms eat and grow well on a paraformaldehyde (PFA)-treated E. coli food source, recommending the use of 0.5% PFA-killed bacteria as a nematode food source for metabolic experiments.

    • Safa Beydoun
    • Hyo Sub Choi
    • Scott F. Leiser
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9