Nature Search

Author Correction: Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Zhao Ma
Jin Li
Yuanpei Li
Amendments and CorrectionsOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1
A metabolome atlas of the aging mouse brain

Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes during aging.

Jun Ding
Jian Ji
Oliver Fiehn
ResearchOpen Access15 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.

Zhao Ma
Jin Li
Yuanpei Li
ResearchOpen Access15 Sept 2020
Nature Communications

Volume: 11, P: 1-12
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Mutations in the gene HADHA result in mitochondrial tri-functional protein (MTP) deficiency and can result in sudden infant death syndrome for which there is no treatment. Here the authors show that the MTP deficient pathology in human cardiomyocytes leads to an abnormal cardiolipin pattern and suggests that cardiolipin affecting compounds may serve as a potential therapy.

Jason W. Miklas
Elisa Clark
Hannele Ruohola-Baker
ResearchOpen Access11 Oct 2019
Nature Communications

Volume: 10, P: 1-21
Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Jason W. Miklas
Elisa Clark
Hannele Ruohola-Baker
Amendments and CorrectionsOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

By comparing the metabolomes, transcriptomes and epigenomes of human pluripotent stem cell lines, Sperber et al. show that interplay between the metabolome and histone modifications drives the metabolic switch from naive to primed pluripotency.

Henrik Sperber
Julie Mathieu
Hannele Ruohola-Baker
Research16 Nov 2015
Nature Cell Biology

Volume: 17, P: 1523-1535
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics

An integrated cheminformatics workflow aids the functional and structural annotation of unknown metabolites found across multiple biological systems.

Zijuan Lai
Hiroshi Tsugawa
Oliver Fiehn
Research27 Nov 2017
Nature Methods

Volume: 15, P: 53-56
Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice

Lan N. Tu
Megan R. Showalter
Vimal Selvaraj
ResearchOpen Access21 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
Generation and quality control of lipidomics data for the alzheimer’s disease neuroimaging initiative cohort

Dinesh Kumar Barupal
Sili Fan
Oliver Fiehn
ResearchOpen Access20 Nov 2018
Scientific Data

Volume: 5, P: 1-13

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