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Showing 1–5 of 5 results

Advanced filters: Author: Mehmet Fatih Bolukbasi Clear advanced filters

Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing

Mehmet Fatih Bolukbasi
Pengpeng Liu
Scot A. Wolfe
Amendments and CorrectionsOpen Access10 Dec 2018
Nature Communications

Volume: 9, P: 1
Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing

Therapeutic genome engineering relies on the development of reliable, robust and versatile tools. Here the authors develop Cas9-Cas9 chimeras with high target site activity that generate predictable deletions.

Mehmet Fatih Bolukbasi
Pengpeng Liu
Scot A. Wolfe
ResearchOpen Access19 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery

This review describes methods for increasing the activity and accuracy of the CRISPR-Cas9 system and discusses approaches for assessing off-target cleavage.

Mehmet Fatih Bolukbasi
Ankit Gupta
Scot A Wolfe
Reviews30 Dec 2015
Nature Methods

Volume: 13, P: 41-50
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.

Hao Yin
Chun-Qing Song
Daniel G Anderson
Research13 Nov 2017
Nature Biotechnology

Volume: 35, P: 1179-1187
DNA-binding-domain fusions enhance the targeting range and precision of Cas9

Fusing a DNA-binding domain to Cas9 with an attenuated, more promiscuous PAM-recognition domain increases the targeting range of Cas9 as well as its specificity.

Mehmet Fatih Bolukbasi
Ankit Gupta
Scot A Wolfe
Research19 Oct 2015
Nature Methods

Volume: 12, P: 1150-1156