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Showing 1–14 of 14 results
Advanced filters: Author: Mehmet Fatih Yanik Clear advanced filters
  • Nature Biotechnology asks a selection of faculty about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications.

    • Nasim Annabi
    • Matthew Baker
    • Jianbin Wang
    Special Features
    Nature Biotechnology
    Volume: 39, P: 281-286
  • The nematodeCaenorhabditis elegans is a widely used model organism for visualizing development, ageing and other phenomena, but high-throughput imaging requires immobilization of the animal. Rohde and Yanik report a rapid immobilization and imaging method for the high-throughput screening of C. elegans.

    • Christopher B. Rohde
    • Mehmet Fatih Yanik
    Research
    Nature Communications
    Volume: 2, P: 1-7
  • Large-scale screening of animal phenotypes requires automated detection and analysis of complex morphological information. Here, Yanik and colleagues present an imaging system based on optical projection tomography that generates micrometre-resolution 3D images of zebrafish larvae with within tens of seconds per animal.

    • Carlos Pardo-Martin
    • Amin Allalou
    • Mehmet Fatih Yanik
    Research
    Nature Communications
    Volume: 4, P: 1-9
  • A scheme for dynamically tuning the coupling between a series of resonators and waveguides provides a means of storing light on an integrated photonic chip for longer than is possible with conventional slow-light systems.

    • Mehmet Fatih Yanik
    • Shanhui Fan
    News & Views
    Nature Physics
    Volume: 3, P: 372-374
  • Non-invasive manipulation of brain circuits with molecular and spatial specificity could revolutionize the treatment of brain disorders. Here, the authors remotely concentrate and deliver drugs to focal brain regions without compromising the blood-brain barrier using novel ultrasound sequences and drug carriers.

    • Mehmet S. Ozdas
    • Aagam S. Shah
    • Mehmet Fatih Yanik
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • A platform for rapid and automated imaging and laser manipulation of zebrafish larvae is presented. It should permit large-scale chemical and genetic screens in this vertebrate organism.

    • Carlos Pardo-Martin
    • Tsung-Yao Chang
    • Mehmet Fatih Yanik
    Research
    Nature Methods
    Volume: 7, P: 634-636
  • Techniques to perform long-term recordings of brain activity from different areas are key to investigating many processes. Here, the authors introduce a tentacular implant with many independent fibers to track neuronal ensembles spanning multiple brain areas for months.

    • Tansel Baran Yasar
    • Peter Gombkoto
    • Mehmet Fatih Yanik
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • The use of deep neural networks for the automated analysis of behavioural videos has emerged as a tool in neuroscience, medicine and psychology. Marks and colleagues present a pipeline capable of tracking and identifying animals, as well as classifying individual and interacting animal behaviour in video recordings and even in complex environments.

    • Markus Marks
    • Qiuhan Jin
    • Mehmet Fatih Yanik
    Research
    Nature Machine Intelligence
    Volume: 4, P: 331-340
  • Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm that predicts the most effective drug combinations to normalize both the activity patterns and the animal behavior.

    • Mostafa Ghannad-Rezaie
    • Peter M. Eimon
    • Mehmet Fatih Yanik
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13
  • Large scale synapse assays can facilitate identification of drug leads. Shiet al. develop a 'synapse microarray' technology that enables sensitive, high-throughput, quantitative screening of synaptogenic events, and use it to identify novel histone deacetylase inhibitors that enhance synaptogenesis.

    • Peng Shi
    • Mark A. Scott
    • Mehmet Fatih Yanik
    Research
    Nature Communications
    Volume: 2, P: 1-10
  • One challenge in drug screening for neurological disorders is how to accurately capture disease pathology and side effects. Here, the authors developed a multi-channel recording platform based on a zebrafish genetic model of epilepsy to screen for antiepileptic drugs.

    • Peter M. Eimon
    • Mostafa Ghannad-Rezaie
    • Mehmet Fatih Yanik
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14