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Showing 1–2 of 2 results
Advanced filters: Author: Mehmet G. Badur Clear advanced filters

  • In xenograft tumour models in mice, modulation of dietary serine, serine palmitoyltransferase or phosphoglycerate dehydrogenase activity enables control of the endogenous synthesis of deoxysphingolipids, sensitizing the tumours to metabolic stress and slowing their progression.

    • Thangaselvam Muthusamy
    • Thekla Cordes
    • Christian M. Metallo
    Research
    Nature
    Volume: 586, P: 790-795

  • β-cell dysfunction in diabetes is caused by glucose and inflammation toxicity. Here, Fu et al. show that β-cell glucose metabolism can be protective though pyruvate carboxylase–mediated shunting of arginine to ureagenesis and away from toxic nitric oxide production, thus suppressing inflammation.

    • Accalia Fu
    • Juan Carlos Alvarez-Perez
    • Nika N. Danial
    Research
    Nature Metabolism
    Volume: 2, P: 432-446