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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T_H17 cell immunity

Regulatory T (T_reg) cells are functionally heterogeneous, yet how each T_reg cell subset exerts its suppressor function remains unresolved. Lin et al. identify IL-27 as a key T_reg cell effector molecule selectively required for gut T_H17 cell regulation.

Chia-Hao Lin
Cheng-Jang Wu
Li-Fan Lu
Research06 Nov 2023
Nature Immunology

Volume: 24, P: 2108-2120
Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma

Mei-Chi Hsu
Jenn-Ren Hsiao
Yao Chang
Research23 Jul 2010
Modern Pathology

Volume: 23, P: 1393-1403

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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity

Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma

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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T_H17 cell immunity