Mutations in the Lbk1 tumour suppressor gene are found in the squamous carcinoma subtype of non-small cell lung cancers for the first time. In a mouse model for lung cancer in which Lkb1 loss is combined with Kras mutations, more aggressive tumours arise than with Kras mutations alone and often these are classified as squamous carcinomas, thus Lkb1 loss modulates lung cancer differentiation.
- Hongbin Ji
- Matthew R. Ramsey
- Kwok-Kin Wong
