Nature Search

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Leukemia inhibitory factor receptor (LIFR) is frequently downregulated in liver cancer. Here the authors show that loss of LIFR promotes liver tumorigenesis and confers resistance to drug-induced ferroptosis through NF-κB-mediated upregulation of iron-sequestering cytokine LCN2.

Fan Yao
Yalan Deng
Li Ma
ResearchOpen Access17 Dec 2021
Nature Communications

Volume: 12, P: 1-17
Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets

The molecular heterogeneity of primary liver cancer remains to be characterised. Here, the authors perform multi-omics analysis of 259 primary liver cancer tissues and identify three distinct molecular subtypes.

Masashi Fujita
Mei-Ju May Chen
Hidewaki Nakagawa
ResearchOpen Access29 Oct 2022
Nature Communications

Volume: 13, P: 1-11
Effect of cold provocation on vessel density in eyes with primary open angle glaucoma: An optical coherence tomography angiography study

Wei-Yi Chou
Catherine Jui-Ling Liu
Yu-Chieh Ko
ResearchOpen Access28 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis

Chun-Jung Ko
Ting-Wei Hsu
Ming-Shyue Lee
Research10 Aug 2020
Oncogene

Volume: 39, P: 5950-5963
A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

Sean D. Schoville
Yolanda H. Chen
Stephen Richards
ResearchOpen Access31 Jan 2018
Scientific Reports

Volume: 8, P: 1-18
Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma

Tzu-Yu Hou
Tung-Mei Kuang
Mei-Ju Chen
ResearchOpen Access27 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma

Ying Mei et al. identify a four-gene tumor immune-relevant signature that predicts the overall survival of melanoma patients and their response to the CTLA4 antibody ipilimumab. This study suggests a potential utility of this four-gene signature in prognosis, risk assessment, and prediction of anti-CTLA4 response in melanoma patients.

Ying Mei
Mei-Ju May Chen
Li Ma
ResearchOpen Access22 Mar 2021
Communications Biology

Volume: 4, P: 1-12
Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells

Daniel Tsung-Ning Huang
Chun-Yi Lu
Li-Min Huang
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-10

Search

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets

Effect of cold provocation on vessel density in eyes with primary open angle glaucoma: An optical coherence tomography angiography study

Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis

A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma

A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma

Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells

Search

Quick links

Search

Filter By:

Search

Quick links