Chronic obstructive pulmonary disease (COPD) is now known to be a heterogeneous disorder, hence the pressing need to develop imaging biomarkers to differentiate between the broad range of COPD phenotypes–all of which require different treatments. Here, Craig Galban and his colleagues have adapted the parametric response map technique for the voxel-by-voxel classification analysis of CT lung images taken from a national COPD trial, providing a more objective characterization of the phenotypic contributions of functional small airways disease and emphysema in COPD.
- Craig J Galbán
- Meilan K Han
- Brian D Ross
