Nature Search

Cadonilimab plus chemotherapy with or without bevacizumab as first-line treatment for advanced cervical cancer: subgroup analyses from the COMPASSION-16 phase 3 trial

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Yang Sun
Hongying Yang
Xiaohua Wu
ResearchOpen Access14 Mar 2026
Nature Communications

P: 1-10
Gotistobart or docetaxel in metastatic squamous non-small cell lung cancer: stage 1 of the randomized phase 3 PRESERVE-003 trial

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Byoung Chul Cho
Rama Balaraman
Yi-Long Wu
ResearchOpen Access27 Mar 2026
Nature Medicine

P: 1-9
NALIRIFOX versus gemcitabine plus nab-paclitaxel in Chinese patients with advanced pancreatic adenocarcinoma: a randomized, open-label phase II trial

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Chuntao Gao
Yanqiao Zhang
Jihui Hao
ResearchOpen Access16 Jan 2026
Nature Communications

Volume: 17, P: 1-11
Structural basis for the assembly and energy transfer between the cyanobacterial PSI core and the double-layered IsiA proteins

Iron limitation induces the expression of IsiA in cyanobacteria, which serves as a light-harvesting antenna for PSI. Here, authors present two PSI-IsiA structures, elucidating the assembly and functional dynamics of these complexes under iron stress.

Long Si
Yingyue Zhang
Mei Li
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-12
CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Jia Liu
Jianwei Yang
Lin Shen
ResearchOpen Access16 Jul 2025
Nature Medicine

Volume: 31, P: 3028-3036
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Yan Song
Bo Zhang
Jing Huang
ResearchOpen Access02 Feb 2023
Nature Medicine

Volume: 29, P: 473-482
Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node

Combination radiotherapy (RT) + αPD-L1 enhances tumor control via a tumor-draining lymph node (TdLN)-derived CD8+ PD-1+ TCF-1+ T cells. RT + αPD-L1 induces a novel LY6A+ subset in the TdLN that migrates to the tumor and differentiates into effectors.

Yang Shen
Erin Connolly
Zachary S. Buchwald
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-15
PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice

Jinkyu Jung
Eric L. Schneider
Daniel V. Santi
ResearchOpen Access19 Jun 2024
Scientific Reports

Volume: 14, P: 1-8
Genomic selection and genetic architecture of agronomic traits during modern rapeseed breeding

Whole-genome resequencing of 418 diverse rapeseed accessions and genome-wide association analyses for 56 agronomic traits provide insights into the genetic architecture and artificial selection or adaptation during modern rapeseed breeding.

Jihong Hu
Biyun Chen
Xiaoming Wu
Research28 Apr 2022
Nature Genetics

Volume: 54, P: 694-704
Structural basis of LhcbM5-mediated state transitions in green algae

High-resolution structures of the PSI–LHCI–LHCII supercomplex from Chlamydomonas reinhardtii reveal the mechanism of assembly between the PSI–LHCI complex and two phosphorylated LHCII trimers.

Xiaowei Pan
Ryutaro Tokutsu
Mei Li
Research08 Jul 2021
Nature Plants

Volume: 7, P: 1119-1131
How to choose an organization pattern in the innovation of the complex product systems: findings from fsQCA

Jie Hou
Meili Zhang
Zeyu Xing
ResearchOpen Access01 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-10
Ultrasmall Glutathione-Protected Gold Nanoclusters as Next Generation Radiotherapy Sensitizers with High Tumor Uptake and High Renal Clearance

Xiao-Dong Zhang
Zhentao Luo
Jianping Xie
ResearchOpen Access02 Mar 2015
Scientific Reports

Volume: 5, P: 1-7
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial

Dan-Yun Ruan
Wen-Wen Huang
Hongyun Zhao
ResearchOpen Access28 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-12
NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination

Zhen Chen
Weilong Wang
Xiumin Li
ResearchOpen Access18 Nov 2024
Cell Death Discovery

Volume: 10, P: 1-13

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