Bone marrow mesenchymal stem cells (BMSC) or BMSC-derived exosome transplantation improves rat ovarian function after chemotherapy-induced ovarian failure. Furthermore, transfer of miR-144-5p using BMSC-derived exosomes decreases granulosa cell (GCs) apoptosis via the PTEN pathway. Thus, a cell-free therapeutic strategy may be possible for ovarian failure.
- Meiling Yang
- Li Lin
- Xiaolan Zhu