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Showing 1–8 of 8 results
Advanced filters: Author: Melanie R. Neeland Clear advanced filters

  • Food allergy is triggered by IgE, but some individuals are not allergic to peanuts despite making peanut-specific IgE, and are considered peanut-tolerant. Here, the authors identify differences in blood immune cell composition of peanut-allergic and tolerant infants using mass cytometry, which may help uncover the mechanism of allergic tolerance.

    • Melanie R. Neeland
    • Sandra Andorf
    • Kari C. Nadeau
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Childhood infection with SARS CoV2 is associated with a milder course of infection but the immunopathogenesis of this remains unclear. Here the authors explore immunological differences in the innate immune system during acute and convalescent SARS CoV2 infection in the young.

    • Melanie R. Neeland
    • Samantha Bannister
    • Richard Saffery
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-5

  • Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.

    • Shidan Tosif
    • Melanie R. Neeland
    • Nigel W. Crawford
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Immunoglobulin E (IgE)-mediated food allergy is a major issue that affects 2–10% of infants. Here the authors study the epigenetic regulation of the naive CD4+ T cell activation response among children with IgE-mediated food allergy finding epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex.

    • David Martino
    • Melanie Neeland
    • Richard Saffery
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heterotypic reactivity to SARS-CoV-2.

    • Kevin J. Selva
    • Carolien E. van de Sandt
    • Amy W. Chung
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Wurzel et al. describe the kinetics of the immune response in relation to clinical and virological features in a 5-month old infant with congenital heart disease and severe COVID-19. The immune response was characterised by an elevated inflammatory response in the acute phase of infection, followed by Th2 skewing and prolonged T cell activation.

    • Danielle Wurzel
    • Melanie R. Neeland
    • Nigel W. Crawford
    ResearchOpen Access
    Communications Medicine
    Volume: 1, P: 1-7