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Showing 1–2 of 2 results
Advanced filters: Author: Melbert D. Saflor Clear advanced filters

  • The success of KRAS G12C mutation specific inhibitors in patients with KRAS-driven tumours is limited by the emergence of acquired resistance. Here, the authors characterise olomorasib, a next-generation covalent KRAS G12C-mutant inhibitor, demonstrating efficacy in the presence of clinically relevant resistance mutations in preclinical KRAS-driven cancer models.

    • Shengbin Peng
    • Youyan Zhang
    • Xueqian Gong
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • GPR40 is a G-protein coupled receptor that binds to free fatty acids, mediating insulin and incretin secretion. Here, the authors present the crystal structure of human GPR40 with an agonist bound to an allosteric site located near the lipid-rich region that suggests a mechanism for biased agonism.

    • Joseph D. Ho
    • Betty Chau
    • Chafiq Hamdouchi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11