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Advanced filters: Author: Melih Acar Clear advanced filters

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

Haematopoietic stem cells normally reside in a bone marrow niche but they are recruited to the spleen after physiological stresses; here, endothelial cells and stromal cells around sinusoidal blood vessels of the spleen are shown to secrete key niche factors to support this process.

Christopher N. Inra
Bo O. Zhou
Sean J. Morrison
Research16 Nov 2015
Nature

Volume: 527, P: 466-471
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

α-catulin is identified as a marker to locate functional haematopoiteic stem cells in deep imaging experiments of bone marrow, showing that α-catulin–GFP⁺c-kit⁺ cells commonly reside in perisinusoidal niches throughout the bone marrow.

Melih Acar
Kiranmai S. Kocherlakota
Sean J. Morrison
Research23 Sept 2015
Nature

Volume: 526, P: 126-130
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea

Sungsu Lee
Jae-Jun Song
Yehoash Raphael
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-15