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Showing 1–2 of 2 results
Advanced filters: Author: Melinde Wijers Clear advanced filters

  • When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.

    • Darren J. Baker
    • Bennett G. Childs
    • Jan M. van Deursen
    Research
    Nature
    Volume: 530, P: 184-189

  • Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hypercholesterolemia in dogs and mice, providing new insights into regulation of cholesterol homeostasis.

    • Paulina Bartuzi
    • Daniel D. Billadeau
    • Bart van de Sluis
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11