Nature Search

Carbon-monoxide-driven bioethanol production operates through a tungsten-dependent catalyst

Microbial alcohol production from waste gases could enable sustainable carbon cycling. Now, the tungsten-dependent aldehyde:ferredoxin oxidoreductase from the gas-converting bacterium Clostridium autoethanogenum has been biochemically and structurally characterized. This monomeric enzyme is responsible for acetate reduction to acetaldehyde, the key step of ethanol production in this industrial microorganism.

Olivier N. Lemaire
Mélissa Belhamri
Tristan Wagner
ResearchOpen Access29 Oct 2025
Nature Chemical Biology

Volume: 22, P: 28-36
Molecular identification of the wheat male fertility gene Ms1 and its prospects for hybrid breeding

Heterosis can rapidly boost yield in crop species but development of hybrid-breeding systems for bread wheat remains a challenge. Here, Tucker et al. describe the molecular identification of the wheat Ms1 gene and discuss its potential for large-scale hybrid seed production in wheat.

Elise J. Tucker
Ute Baumann
Ryan Whitford
ResearchOpen Access11 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

Philip J. Law
Sonja I. Berndt
Susan Slager
ResearchOpen Access06 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Genome-wide association study identifies five susceptibility loci for glioma

Richard Houlston, Melissa Bondy and colleagues identify variants at five loci associated with glioma susceptibility, providing insights into the etiology of this primary brain tumor. The risk loci include common variants near TERT, CDKN2A-CDKN2B and RTEL1.

Sanjay Shete
Fay J Hosking
Richard S Houlston
Research05 Jul 2009
Nature Genetics

Volume: 41, P: 899-904
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Ian PM Tomlinson
Emily Webb
Richard S Houlston
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 623-630
Genome-wide association study identifies multiple susceptibility loci for glioma

Using meta-analysis of previous genome-wide association studies against the latest reference variant databases, this work identifies five new risk loci for glioblastoma and non-glioblastoma type of glioma.

Ben Kinnersley
Marianne Labussière
Richard S. Houlston
ResearchOpen Access01 Oct 2015
Nature Communications

Volume: 6, P: 1-9
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associated with BMI.

Cathy E Elks
John R B Perry
Anna Murray
Research21 Nov 2010
Nature Genetics

Volume: 42, P: 1077-1085
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for low-trauma bone fracture.

Karol Estrada
Unnur Styrkarsdottir
Fernando Rivadeneira
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 491-501
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Rosalind Eeles and colleagues report a multistage genome-wide association study of prostate cancer, identifying seven new prostate cancer susceptibility loci.

Zsofia Kote-Jarai
Ali Amin Al Olama
Rosalind A Eeles
Research10 Jul 2011
Nature Genetics

Volume: 43, P: 785-791
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the spinal cord and brain motor centers in adult pigs and non-human primates.

Mariana Bravo-Hernandez
Takahiro Tadokoro
Martin Marsala
Research23 Dec 2019
Nature Medicine

Volume: 26, P: 118-130
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

The most common genetic cause of ALS and frontal temporal dementia—hexanucleotide repeat expansion in C9orf72—is shown to provoke disease via synergy of gain of toxicity(ies) from repeat-encoded RNAs/dipeptide repeat proteins and reduction in the C9ORF72 protein.

Qiang Zhu
Jie Jiang
Don W. Cleveland
Research13 Apr 2020
Nature Neuroscience

Volume: 23, P: 615-624
Evolution in action: habitat transition from sediment to the pelagial leads to genome streamlining in Methylophilaceae

Michaela M. Salcher
Daniel Schaefle
Rohit Ghai
ResearchOpen Access10 Jul 2019
The ISME Journal

Volume: 13, P: 2764-2777
Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements

Kendra A Ross
Abbigail W Bigham
Esteban J Parra
Research17 Jun 2010
Journal of Human Genetics

Volume: 55, P: 582-589
Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory

Ruth M Barrett
Melissa Malvaez
Marcelo A Wood
Research20 Apr 2011
Neuropsychopharmacology

Volume: 36, P: 1545-1556

Search

Carbon-monoxide-driven bioethanol production operates through a tungsten-dependent catalyst

Molecular identification of the wheat male fertility gene Ms1 and its prospects for hybrid breeding

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Genome-wide association study identifies five susceptibility loci for glioma

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Genome-wide association study identifies multiple susceptibility loci for glioma

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

A second update on mapping the human genetic architecture of COVID-19

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

Evolution in action: habitat transition from sediment to the pelagial leads to genome streamlining in Methylophilaceae

Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements

Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory

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