Nature Search

Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa

Evidence that a dry-season outbreak of malaria in Dire Dawa, Ethiopia is caused by Anopheles stephensi carrying Plasmodium falciparum with diagnostic and drug resistance mutations calls for heightened vector surveillance in both urban and rural settings.

Tadele Emiru
Dejene Getachew
Fitsum G. Tadesse
ResearchOpen Access26 Oct 2023
Nature Medicine

Volume: 29, P: 3203-3211
Global patterns and climatic controls of forest structural complexity

Forest structure depends both on extrinsic factors such as climate and on intrinsic properties such as community composition and diversity. Here, the authors use a dataset of stand structural complexity based on LiDAR measurements to build a global map of structural complexity for primary forests, and find that precipitation variables best explain global patterns of forest structural complexity.

Martin Ehbrecht
Dominik Seidel
Christian Ammer
ResearchOpen Access22 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

Several 17B-HSD13 variants have been identified as protective against NASH/MASH. However the protein’s endogenous function is unknown. Here authors describe sulfonamide-based inhibitors and synthetic substrates, then apply to multiple cellular systems revealing that the most prevalent IsoD variant maintains NAD-dependent catalytic activity.

Michelle R. Garnsey
Yang Wang
Michelle F. Clasquin
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Julien Bryois
Nathan G. Skene
Patrick F. Sullivan
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 482-493
The endocrine complications of cystic fibrosis

Cystic fibrosis is associated with multiple endocrine complications, which are caused by systemic dysfunction of the cystic fibrosis transmembrane conductance regulator protein. In this Review, Moheet and colleagues describe these conditions, with particular emphasis on the effects of CFTR modulator therapy, as well as the challenges related to ageing in people with cystic fibrosis.

Amir Moheet
Kevin J. Scully
Melissa S. Putman
Reviews31 Oct 2025
Nature Reviews Endocrinology

P: 1-15
Spatial variation in the non-use of modern contraception and its predictors in Bangladesh

Md Nuruzzaman Khan
Melissa L. Harris
ResearchOpen Access24 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Green gentrification in European and North American cities

The relationship between new greenspaces and gentrification is an important one for urbanization. Here the authors show a positive relationship for at least one decade between greening in the 1990s–2000s and gentrification that occurred between 2000–2016 in 17 of 28 studied cities in North America and Europe.

Isabelle Anguelovski
James J. T. Connolly
Joaquin Martinez Minaya
ResearchOpen Access02 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

A wireless ‘smart’ bandage stimulates wound healing.

Yuanwen Jiang
Artem A. Trotsyuk
Zhenan Bao
Research24 Nov 2022
Nature Biotechnology

Volume: 41, P: 652-662
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show that the 2D crystal enclosing this so-called phage nucleus is an assembly of tetramers linked by flexible loops and tails.

Eliza S. Nieweglowska
Axel F. Brilot
David A. Agard
ResearchOpen Access18 Feb 2023
Nature Communications

Volume: 14, P: 1-12
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping

In this study Fossati et al. demonstrate how co-fractionation mass spectrometry can be applied to systematically investigate pathogen proteome organization and host interactome plasticity upon Jumbophage infection of Pseudomonas aeruginosa.

Andrea Fossati
Deepto Mozumdar
Danielle L. Swaney
ResearchOpen Access24 Aug 2023
Nature Communications

Volume: 14, P: 1-16
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Indigenous-led designation and management of culturally significant species

Indigenous-led structured decision-making workshops with local Indigenous people on Bundjalung Country in Australia identified and prioritized culturally significant species and determined Bundjalung-led actions for the management of these culturally significant entities.

Teagan Goolmeer
Oliver Costello
Brendan A. Wintle
Research01 Aug 2024
Nature Ecology & Evolution

Volume: 8, P: 1623-1631
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
Benchmarking performance of annual burn probability modeling against subsequent wildfire activity in California

Christopher J. Moran
Matthew P. Thompson
Melissa R. Jaffe
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Evidence for quorum sensing and differential metabolite production by a marine bacterium in response to DMSP

Winifred M Johnson
Melissa C Kido Soule
Elizabeth B Kujawinski
ResearchOpen Access16 Feb 2016
The ISME Journal

Volume: 10, P: 2304-2316
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
The impact of implementing and sustaining the international guidelines for skin-to-skin contact in the first hour after birth in Uganda

Kajsa Brimdyr
Scovia Nalugo Mbalinda
Karin Cadwell
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-8
Expression patterns reveal niche diversification in a marine microbial assemblage

Scott M Gifford
Shalabh Sharma
Mary Ann Moran
Research30 Aug 2012
The ISME Journal

Volume: 7, P: 281-298
Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria

Chris R. Reisch
Melissa J. Stoudemayer
William B. Whitman
Research11 May 2011
Nature

Volume: 473, P: 208-211
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing

Anthony Bleyer, Eric Lander, Mark Daly and colleagues show that frameshift mutations in a large VNTR of MUC1 cause medullary cystic kidney disease type 1. Their discovery sheds light on the biology of this disease and highlights challenges in using massively parallel sequencing technologies to characterize certain types of sequence variants.

Andrew Kirby
Andreas Gnirke
Mark J Daly
Research10 Feb 2013
Nature Genetics

Volume: 45, P: 299-303
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921
Deep learning models for histologic grading of breast cancer and association with disease prognosis

Ronnachai Jaroensri
Ellery Wulczyn
Po-Hsuan Cameron Chen
ResearchOpen Access04 Oct 2022
npj Breast Cancer

Volume: 8, P: 1-12
Determining breast cancer biomarker status and associated morphological features using deep learning

Gamble and Jaroensri et al. develop deep learning systems to predict breast cancer biomarker status using H&E images. Their models enable slide-level and patch-level predictions for ER, PR and HER2, with interpretability analyses highlighting specific histological features associated with these markers.

Paul Gamble
Ronnachai Jaroensri
Po-Hsuan Cameron Chen
ResearchOpen Access14 Jul 2021
Communications Medicine

Volume: 1, P: 1-12
Interpretable survival prediction for colorectal cancer using deep learning

Ellery Wulczyn
David F. Steiner
Craig H. Mermel
ResearchOpen Access19 Apr 2021
npj Digital Medicine

Volume: 4, P: 1-13
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever

Mercedeh Movassagh
Lisa M. Bebell
Joseph N. Paulson
ResearchOpen Access10 Sept 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-10
Predicting prostate cancer specific-mortality with artificial intelligence-based Gleason grading

Wulczyn et al. utilise a deep learning-based Gleason grading model to predict prostate cancer-specific mortality in a retrospective cohort of radical prostatectomy patients. Their model enables improved risk stratification compared to pathologists’ grading and demonstrates the potential for computational pathology in the management of prostate cancer.

Ellery Wulczyn
Kunal Nagpal
Craig H. Mermel
ResearchOpen Access30 Jun 2021
Communications Medicine

Volume: 1, P: 1-8
Prospective validation of smartphone-based heart rate and respiratory rate measurement algorithms

Bae et al. prospectively evaluated smartphone camera-based techniques for measuring heart rate and respiratory rate. They found measurements were accurate across a range of pre-defined subgroups.

Sean Bae
Silviu Borac
Ming Jack Po
ResearchOpen Access12 Apr 2022
Communications Medicine

Volume: 2, P: 1-10
Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Xiaoming Jia
Fernando S. Goes
Laura J. Scott
ResearchOpen Access22 Jan 2021
Molecular Psychiatry

Volume: 26, P: 5239-5250
Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection

Béré K. Diallo
Caitlín Ní Chasaide
Kingston H. G. Mills
ResearchOpen Access13 May 2023
npj Vaccines

Volume: 8, P: 1-13
A longitudinal resource for studying connectome development and its psychiatric associations during childhood

Russell H. Tobe
Anna MacKay-Brandt
Michael P. Milham
ResearchOpen Access14 Jun 2022
Scientific Data

Volume: 9, P: 1-24
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Delnaz Roshandel
Eric J. Sanders
Helen Cockerill
ResearchOpen Access28 Sept 2023
npj Genomic Medicine

Volume: 8, P: 1-11
Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer

Kanchan Singh
Melissa A. Pruski
Jennifer M. Bailey
Research30 Sept 2019
Oncogene

Volume: 39, P: 1152-1164
Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Xiaoming Jia
Fernando S. Goes
Laura J. Scott
Amendments and Corrections05 Mar 2021
Molecular Psychiatry

Volume: 26, P: 5251

Search

Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa

Global patterns and climatic controls of forest structural complexity

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

The endocrine complications of cystic fibrosis

Spatial variation in the non-use of modern contraception and its predictors in Bangladesh

Green gentrification in European and North American cities

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

An integrated encyclopedia of DNA elements in the human genome

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

One thousand plant transcriptomes and the phylogenomics of green plants

Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Indigenous-led designation and management of culturally significant species

A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

Benchmarking performance of annual burn probability modeling against subsequent wildfire activity in California

Evidence for quorum sensing and differential metabolite production by a marine bacterium in response to DMSP

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

The impact of implementing and sustaining the international guidelines for skin-to-skin contact in the first hour after birth in Uganda

Expression patterns reveal niche diversification in a marine microbial assemblage

Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria

Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing

Initial sequencing and analysis of the human genome

Deep learning models for histologic grading of breast cancer and association with disease prognosis

Determining breast cancer biomarker status and associated morphological features using deep learning

Interpretable survival prediction for colorectal cancer using deep learning

Vaginal microbiome topic modeling of laboring Ugandan women with and without fever

Predicting prostate cancer specific-mortality with artificial intelligence-based Gleason grading

Prospective validation of smartphone-based heart rate and respiratory rate measurement algorithms

Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection

A longitudinal resource for studying connectome development and its psychiatric associations during childhood

SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer

Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

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