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Showing 1–3 of 3 results

Advanced filters: Author: Melissa S. Gildenberg Clear advanced filters

Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis

Pol ι forms Hoogsteen base pairs with the incoming nucleotide. Here, the authors use time-lapse X-ray crystallography to show that Hoogsten base pairing is maintained within the pol ι active site throughout the nucleotide incorporation reaction.

Zach Frevert
Devin T. Reusch
M. Todd Washington
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Probing the Transmembrane Structure and Topology of Microsomal Cytochrome-P450 by Solid-State NMR on Temperature-Resistant Bicelles

Kazutoshi Yamamoto
Melissa Gildenberg
Ayyalusamy Ramamoorthy
ResearchOpen Access30 Aug 2013
Scientific Reports

Volume: 3, P: 1-6
Structure of DNA polymerase ζ: capturing the getaway driver

During translesion synthesis, eukaryotic DNA polymerase ζ carries out extension from a wide range of DNA lesions. Elucidation of the cryo-EM structure of polymerase ζ reveals how the enzyme catalyzes DNA strand synthesis beyond the lesion.

M. Todd Washington
Melissa S. Gildenberg
News & Views25 Aug 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1-2