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Molecular Psychiatry (1)
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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Regulation of cell polarity is key to ensure directed cell migration. Here, Atkins et al. identify the primary cilium cAMP/cGMP ratio as a master regulator of the cell polarity of migrating cortical interneurons downstream of the CXCL12 chemokine.

Melody Atkins
Maud Wurmser
Christine Métin
ResearchOpen Access04 Dec 2023
Nature Communications

Volume: 14, P: 1-17
PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity

Lucie Viou
Melody Atkins
Christine Métin
ResearchOpen Access07 Mar 2024
Molecular Psychiatry

Volume: 29, P: 2296-2307

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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity

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